O le kulupu o statins (kolose-faʻaititia vailaʻau) aofia ai le aoga Lovastatin. Ole vailaʻau e faʻaogaina e le gata i le togafitia o le hypercholesterolemia, hyperlipoproteinemia, ae o le puipuia ai o le cardiovascular faamai.
Ole fualaau faasaina e tatau ona faʻaoga faʻatasi ma se meaʻai faʻapitoa, faʻamalositino ma mamafa mamafa. I lenei tusitusiga, e mafai ona e aʻoaʻo atili e uiga i le Lovastatin, faʻatonuga mo le faʻaaogaina, tau, iloiloga, faʻatusatusa.
Le auala o le gaioiga o le vailaʻau
Lovastatin auai i le vaega o lipid-faʻaititia vailaʻau e solia le tuufaatasiga o kolesterol i le ate i le amataga. O lenei fualaau faasaina ua manatu sili ona maualuga faamuamua i isi statins. E fuaina mai biocultures Aspergillusterreus ma Monascusruber.
Tasi i le faʻaogaina o meaʻai, o le vailaʻau e nono ia lava i aʻafiaga o faʻaogaina o enzymes o loʻo faʻaitiitia ma mitiia lava. Ma le isi, o le tele o le aofaʻi o le vailaʻau, o le vave foi ona faʻaaogaina i totonu o le faʻaʻavega. O le vailaʻau o loʻo faʻasaʻa i totonu o le alatoto, ma ulufale mai i le toto. Le maualuga tapulaa o mea maua ausia ina ua uma 2-4 itula. Ua faʻasolosolo atu i isi vaega uma o le tino e tupu i totonu o le fua o le beta-hydroxy acid.
Ole gaioiga ole Lovastatin e faʻataʻitaʻi i gaioiga e lua. Muamua, e faʻalavelaveina le tuufaatasia o le kolose i totonu o le ate, e taofia ai le suia o le reductase i le melovanate. Lua, e oʻo atu i le faʻamalosia o faʻavavevave catabolism (metabolic decay process) o le LDL. E faʻatusatusa i lenei faʻagasologa, e iai le siʻitia o le HDL, pe o le "lelei" kolesterol.
O le afa-ola o le gaosi oloa e 3 itula. Metabolites ma le gaʻo oloa e faʻatinoina atu e ala i fatugaʻo ma totonu o.
Faʻatonuga mo le faʻaaogaina o le vailaʻau
Lovastatin 20 mg poʻo le 40 mg e maua i le pepa laupepa, o le vaega fai mea e tutusa lona igoa. O isi vaega o le vailaʻau o le lactose monohydrate, starch, cellulose, magnesium stearate, butylhydroxyanisole, citric ma ascorbic acid.
E faʻatau atu se vailaʻau pe a iai se tagata o iai le fomaʻi. A faʻatau le oloa, e tatau i le tagata maʻi ona utagia mai le faʻapipiʻi faʻapipiʻi. O le faʻatonuga e iai ni faʻaaliga mo le faʻaaogaina o lenei vailaʻau.
- togafitiga ile aofaʻi ole hypercholisterinemia, ole IIa ma le IIb;
- togafitiga o le hyperlipoproteinemia (lavelave ma le maʻisuka ma nephrotic syndrome);
- togafiti o aterosklerosis atigi (faatasi ai ma vitamini togafitiga ma unsaturated gaʻo gaʻo);
- puipuia o le mafaufau o faʻasoesa;
- togafitiga mo le hypertriglyceridemia.
Ole faʻaaogaina o fualaau e tatau ona faia 1 taimi ile aso ile taimi ole 'aiga o le afiafi. Ole fua ole fualaau e faalagolago ile faamaʻi. Ma, ma le hyperlipidemia, tasi aula o 10-80 mg ua faatonuina. Togafitiga o pathology amata i laiti laʻititi, i le faʻatagaga a le fomaʻi, e mafai ona faʻasolosolo faʻalauteleina. E fautuaina e filifili se fua ile 4 vaiaso. Ole maualuga ole fualaau (80 mg) e mafai ona vaevaeina ile lua tui - ile taeao ma le afiafi.
I le togafitiga o le aterosklerosis atigi, o le sili ona lelei fua o 20-40 mg. Afai e le aoga le togafitiga, o le siitia i le 60-80 mg e mafai. Afai o le tagata gasegase o lo o ia avea fibrates poʻo le nicotinic acid i le taimi e tasi, Lovastatin e tatau ona faʻaoga le sili atu ma le 20 mg i le aso. Faʻapena foi ona tatau ona faʻaititia le vailaʻau i mea faʻapenei:
- Tuufaʻatasi faʻaaogaina o immunosuppressants.
- Le faʻaaogaina o le vailaʻau sooupu.
- Togafitiga ma antifungal vailaau.
- Togafitiga o faʻamaʻi o le maʻi o se maoti poʻo le lautele etiology.
- Le faʻaaogaina o vailaʻau o loʻo iai anticoagulants.
E manaʻomia le teuina o le vailaʻau ile vevela e le sili atu nai lo le 25 tikeri Celsius.
A maeʻa le aso maliu, lea e 2 tausaga ona faʻasua lea ona faʻaaoga le oloa.
Contraindications ma itu aafiaga
Lovastatin o loʻo i ai foʻi se laʻititi lisi o contraindications. E faʻasaina le faʻaaogaina o le vailaʻau i le tulaga o myopathy (maʻi o le neuromuskular faʻamaʻi), maʻitaga, kolestasis, faʻaleaga o le ate, i lalo o le tausaga 18 tausaga ma le tagata lava ia lagona i mea.
Ole vailaʻau e tatau ona faʻaogaina ma le faʻaeteete i tagata gasegase o loʻo pasia okaina le faʻapipiʻi atigi toto. Leai se tulaga e mafai ai ona inu vai inu ava malosi.
I nisi tulaga, o se vailaʻau mafai mafua ai itu aafiaga. I latou, e taua le faʻalauiloa:
- Tali na fesoʻotaʻi ma galuega a le gastrointestinal tract: osofaʻiga o le maʻi, ulu mimigi, faʻateleina le gasu, suiga o le tofo, manava manava, suia le maʻi suka.
- Faʻalavelave o le totonugalemu o le tino: ulu tiga, le lava le moe, popole, niniva, paresthesia, myositis, maso cramps ma myalgia. A faʻaaogaina le cyclosporine, gemfibrozil poʻo le nicotinic acid, o loʻo iai le avanoa o le rhabdomyolysis.
- Faʻatonuga o le biliary system: faʻateleina gaioiga o bilirubin, alkaline phosphatase, liver transaminases ma creatine phosphokinase. O nisi taimi o hepatitis, cholestatic jaundice ma biliary cholestasis e mafai.
- Alergic tali: gatalia, paʻu paʻu, urticaria, angioedema, arthralgia.
- Faʻaletonu o mata: atrophy o le optic neura ma le atinaʻeina o cataracts.
- Isi aʻafiaga paʻu: faʻaititia le malosi, malaise lautele, alopecia.
Ova le faʻaogaina o vailaʻau pe a ova le tele o fualaʻau o le vailaʻau e le o maitauina. Le faʻavae o togafitiga o le faʻamutaina o le Lovastatin, lavage gastric, o le faʻaaogaina o sorbents (faʻamalosia carbon, Smecta, Polysorb, Atoxil) pulea o taua taua, gaioiga o le fatu ma creatine phosphokinase gaioiga.
Fegalegaleaiga ma isi auala
Lovastatin le tatau ona faʻaaogaina uma vailaʻau, aua latou fegalegaleaiga mafai ona mafua ai le le lelei tali atu o le tino. E le gata i lea, o nisi vailaʻau e mafai ona faʻateleina le totoʻo o gaosi mea, ma nisi e mafai ona faʻaititia.
Ole maualuga ole lamatiaga o le faʻaleagaina o maso ma le myopathy, faʻapea ai ma le faʻateleina o mea o loʻo i ai le mea gaioi, ua faʻaosofia ai le faʻaogaina tutusa ole Lovastatin faʻatasi ai ma le nicotinic acid, Cyclosporine, Ritonavir, Erythromycin, Nefazodon ma Clarithromycin.
Ole lavelave ole faʻaaogaina ole vailaʻau ma le sua o le moli, fenofibrate, gemfibrozil ua faʻateleina ai le avanoa ile myopathy.
E faʻateleina le aʻafia o toto ile faʻaaogaina tutusa ole warfarin. E faʻaitiitia le faʻaavanoaina o le lovastatin pe a faʻaaogaina le colestyramine. Ina ia mafai ai ona ola masani le vailaʻau, e tatau ona faʻaaoga vailaʻau ma se vaitaimi o 2-4 itula.
Faʻatasi ai ma faʻamaʻi pipisi, e tatau i le tagata maʻi ona fefaʻatauaʻi se fomaʻi e uiga i le inuina o fualaau.
O nisi o latou e le o fetaui ma Lovastatin, o le mea lea, o le tutoʻatasi faʻaaogaina vailaʻau e matua faasaina.
Tau, tala faatatau ma gasegase iloiloga
Ae paga lea, i le taimi nei e le mafai ona faʻatau Lovastatin ona E le gaosia i Rusia.
Kamupani faʻafomaʻi vailaʻau e pei o Lekpharm (Belarus), Replekpharm AD (Maketonia) ma Kievmedpreparat (Ukraine) o tagata gaosi ia le vailaʻau.
I lenei tulaga, e mafai ona faatonuina e le fomaʻi se tala faatatau o Lovastatin, lea e tutusa lava togafitiga.
O vailaʻau sili ona lauiloa o:
- Holetar. O loʻo i ai ma le mea aoga - lovastatin, o le mea lea e faʻailoga o le Lovastatin. Ole fualaau ei ai tutusa faailoga, contraindications ma faigata tali mai pei Lovastatin.
- Cardiostatin. O le isi lauiloa vailaau o se uiga tutusa ma Lovastatin, aua o loʻo iai le gutu gaioi. A o aveina Cardiostatin, o se togafitiga aoga ua matauina mo le lua vaiaso, ma le maualuga i le 4-6 vaiaso o le aveina o le fualaau faasaina. O le averesi o le tau o 290 rubles (i totonu o se afifi o 30 papa o 20 mg).
- Pravastatin. E lautele le faʻasologa o gaioiga. O le vaega aoga o le pravastatinum. Ole vailaʻau e faʻaaogaina mo le muamua hypercholesterolemia ma fefiloi dyslipidemia, faʻapea foi mo le puipuia o ischemic fatu fatu. Ole faʻaaogaina ole Pravastatin e mafai ona avea ose puipuiga lona lua mo le myocardial infarction, angina pectoris ma post-transplant hyperlipidemia.
- Zokor. O le vailaau aoga o le fualaau faasaina o simvastatin. O le faʻailoga autu o le vailaʻau o le togafitia o le hypercholesterolemia. Zokor o loo faʻaaogaina foʻi o se valivali e puipuia ai le faʻatupuina o fatugaʻi. Ole tau o le 380 rubles (28 papa o le 10 mg) ma 690 rubles (28 papa o 20 mg).
E tusa ai ma le Vyshkovsky Index, o taʻitaʻi i totonu o vailaʻau a Rusia o Cardiostatin, Mevacor, Holetar ma Rovacor.
Faʻamatalaga i luga o Lovastatin, mai i gasegase ma fomaʻi, e lelei. Ole vailaʻau e saogalemu ma faʻapalepale i tagata mamaʻi, tusa lava pe faʻaaoga umi.
Faʻafitauli e fesoʻotaʻi ma dyspeptic faaletonu taimi e foliga mai i le amataga o togafitiga. Ina ua maeʻa le lua vaiaso, ina ua masani le tino ile faʻamalosiʻau a le vaega na fai, ua muta ai faʻailoga. Mai lea taimi i lea taimi, o tulaga ole ALT ma le AST e faʻateleina, o lea e moomia le faʻatautaia o a latou mea.
I le maeʻa 1,5 masina mai le amataga o le togafitiga, e faia ai loa se suʻesuʻega mulimuli. I le avea ai o se tulafono, o loʻo i ai se tulaga lelei i faʻataʻitaʻiga, i.e. faʻaititia le lipid.
Faʻafefea ona i lalo ifo le kolose o loʻo faʻamatalaina ile vitio i lenei tusitusiga.
